Roop Mallik: From machines to molecular motors
نویسنده
چکیده
Roop Mallik studies how molecular motors and lipids interact to drive intracellular transport.
منابع مشابه
Intracellular Transport: How Do Motors Work Together?
How many motors move cargos on microtubules inside a cell, and how do they work together to achieve regulated transport? A new study uses an optical trap to investigate the motion of protein-bound beads on the surface of flagella to address these questions and comes up with some intriguing answers.
متن کاملMolecular Motors: Strategies to Get Along
The majority of active transport in the cell is driven by three classes of molecular motors: the kinesin and dynein families that move toward the plus-end and minus-end of microtubules, respectively, and the unconventional myosin motors that move along actin filaments. Each class of motor has different properties, but in the cell they often function together. In this review we summarize what is...
متن کاملMonte Carlo modeling of single-molecule cytoplasmic dynein.
Molecular motors are responsible for active transport and organization in the cell, underlying an enormous number of crucial biological processes. Dynein is more complicated in its structure and function than other motors. Recent experiments have found that, unlike other motors, dynein can take different size steps along microtubules depending on load and ATP concentration. We use Monte Carlo s...
متن کاملStudying molecular motor-based cargo transport: what is real and what is noise?
Noise is a major problem in analyzing tracking data of cargos moved by molecular motors. We use Bayesian statistics to incorporate what is known about the noise in parsing the trajectory of a cargo into a series of constant velocity segments. Tracks with just noise and no underlying motion are fit with constant velocity segments to produce a calibration curve of fit quality versus average segme...
متن کاملBuilding Complexity: An In Vitro Study of Cytoplasmic Dynein with In Vivo Implications
BACKGROUND Cytoplasmic dynein is the molecular motor responsible for most retrograde microtubule-based vesicular transport. In vitro single-molecule experiments suggest that dynein function is not as robust as that of kinesin-1 or myosin-V because dynein moves only a limited distance (approximately 800 nm) before detaching and can exert a modest (approximately 1 pN) force. However, dynein-drive...
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